Skip to main content

Foundation for the NIH

Standing With a Remarkable Young Man

Posted on by

Francis Collins and Andrew Lee

It was a pleasure to participate in presenting Andrew Lee with the Charles A. Sanders, M.D., Partnership Award at the annual fall board dinner of the Foundation for the National Institutes of Health (FNIH). The dinner was held on October 24 in Bethesda, MD. The 22-year-old Lee uses his passion for cars to travel the country to raise awareness and funds for rare kidney cancer research in children and young adults. In just over two years, Lee has turned his Driven to Cure, Inc. into an active grassroots movement that has made generous donations to help advance cutting-edge kidney cancer research conducted by the National Cancer Institute at the NIH Clinical Center. The Charles A. Sanders, M.D., Partnership Award is named for the former chairman of the FNIH Board of Directors. Credit: FNIH


Gene Drive Research Takes Aim at Malaria

Posted on by

Mosquitoes and a Double HelixMalaria has afflicted humans for millennia. Even today, the mosquito-borne, parasitic disease claims more than a half-million lives annually [1]. Now, in a study that has raised both hope and concern, researchers have taken aim at this ancient scourge by using one of modern science’s most powerful new technologies—the CRISPR/Cas9 gene-editing tool—to turn mosquitoes from dangerous malaria vectors into allies against infection [2].

The secret behind this new strategy is the “gene drive,” which involves engineering an organism’s genome in a way that intentionally spreads, or drives, a trait through its population much faster than is possible by normal Mendelian inheritance. The concept of gene drive has been around since the late 1960s [3]; but until the recent arrival of highly precise gene editing tools like CRISPR/Cas9, the approach was largely theoretical. In the new work, researchers inserted into a precise location in the mosquito chromosome, a recombinant DNA segment designed to block transmission of malaria parasites. Importantly, this segment also contained a gene drive designed to ensure the trait was inherited with extreme efficiency. And efficient it was! When the gene-drive engineered mosquitoes were mated with normal mosquitoes in the lab, they passed on the malaria-blocking trait to 99.5 percent of their offspring (as opposed to 50 percent for Mendelian inheritance).