human on a chip
Something pretty incredible happens—both visually and scientifically—when researchers spread neural stem cells onto a gel-like matrix in a lab dish and wait to see what happens. Gradually, the cells differentiate and self-assemble to form cohesive organoids that resemble miniature brains!
In this image of a mini-brain organoid, the center consists of a clump of neuronal bodies (magenta), surrounded by an intricate network of branching extensions (green) through which these cells relay information. Scattered throughout the mini-brain are star-shaped astrocytes (red) that serve as support cells.
Tags: 2017 Koch Institute Image Awards, Alzheimer’s disease, astrocytes, brain, brain in a dish, confocal laser scanning microscope, human on a chip, human physiome, hydrogel, induced Pluripotent Stem cells, mini brain, neuronal bodies, organoids, physiome, stem cells, The Koch Institute Galleries, tissue chips
A lot of time, money, and effort are devoted to developing new drugs. Yet only one of every 10 drug candidates entering human clinical trials successfully goes on to receive approval from the Food and Drug Administration (FDA) . Many would-be drugs fall by the wayside because they prove toxic to the brain, liver, kidneys, or other organs—toxicity that, unfortunately, isn’t always detected in preclinical studies using mice, rats, or other animal models. That explains why scientists are working so hard to devise technologies that can do a better job of predicting early on which chemical compounds will be safe in humans.
As an important step in this direction, NIH-funded researchers at the Morgridge Institute for Research and University of Wisconsin-Madison have produced neural tissue chips with many features of a developing human brain. Each cultured 3D “organoid”—which sits comfortably in the bottom of a pea-sized well on a standard laboratory plate—comes complete with its very own neurons, support cells, blood vessels, and immune cells! As described in Proceedings of the National Academy of Sciences , this new tool is poised to predict earlier, faster, and less expensively which new or untested compounds—be they drug candidates or even ingredients in cosmetics and pesticides—might harm the brain, particularly at the earliest stages of development.
Tags: Autism Spectrum Disorder, brain, brain development, brain on a chip, drug development, drug screening, human brain, human on a chip, machine learning, microglia, neural constructs, neural progenitor cells, neural support cells, neural tissue chip, neurodevelopmental disorders, neurology, neurons, neurotoxicity, organoid, RNA sequencing, stem cells, tissue chip, Tissue Chip for Drug Screening Program