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HEAL Initiative

Researchers Elucidate Role of Stress Gene in Chronic Pain

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Credit: Getty Images/simonkr

For most people, pain eventually fades away as an injury heals. But for others, the pain persists beyond the initial healing and becomes chronic, hanging on for weeks, months, or even years. Now, we may have uncovered an answer to help explain why: subtle differences in a gene that controls how the body responds to stress.

In a recent study of more than 1,600 people injured in traffic accidents, researchers discovered that individuals with a certain variant in a stress-controlling gene, called FKBP5, were more likely to develop chronic pain than those with other variants [1]. These findings may point to new non-addictive strategies for preventing or controlling chronic pain, and underscore the importance of NIH-funded research for tackling our nation’s opioid overuse crisis.


Fireside Chat with U. S. Surgeon General

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Francis Collins and Surgeon General Adams

I sat down with U. S. Surgeon General Dr. Jerome Adams for a fireside chat about chronic pain management, the Helping to End Addiction Long-Term (HEAL) Initiative, and the opioid crisis. The event was held as part of the 13th Annual NIH Pain Consortium Symposium.
Credit: Andrew Propp