type 2 diabetes
For obese people with diabetes, doctors have increasingly been offering gastric bypass surgery as a way to lose weight and control blood glucose levels. Short-term results are often impressive, but questions have remained about the long-term benefits of such operations. Now, a large, international study has some answers.
Soon after gastric bypass surgery, about 50 percent of folks not only lost weight but they also showed well-controlled blood glucose, cholesterol, and blood pressure. The good news is that five years later about half of those who originally showed those broad benefits of surgery maintained that healthy profile. The not-so-good news is that the other half, while they generally continued to sustain weight loss and better glucose control, began to show signs of increasing risk for cardiovascular complications.
Tags: bariatric surgery, blood glucose, blood pressure, cardiovascular disease, cholesterol, clinical trial, composite triple endpoint, diabetes, gastric bypass, heart attack, heart disease, hemoglobin A1C, obesity, Roux-en-Y procedure, sleeve gastrectomy, stroke, surgery, type 2 diabetes, weight
People with type 2 diabetes are at increased risk for heart attacks, stroke, and other forms of cardiovascular disease, and at an earlier age than other people. Several years ago, the Food and Drug Administration (FDA) recommended that drug developers take special care to show that potential drugs to treat diabetes don’t adversely affect the cardiovascular system . The challenge in implementing that laudable exhortation is that a drug’s long-term health risks may not become clear until thousands or even tens of thousands of people have received it over the course of many years, sometimes even decades.
Now, a large international study, partly funded by NIH, offers some good news: proof-of-principle that “Big Data” tools can help to identify a drug’s potential side effects much earlier in the drug development process . The study, which analyzed vast troves of genomic and clinical data collected over many years from more than 50,000 people with and without diabetes, indicates that anti-diabetes therapies that lower glucose by targeting the product of a specific gene, called GLP1R, are unlikely to boost the risk of cardiovascular disease. In fact, the evidence suggests that such drugs might even offer some protection against heart disease.
Tags: anti-diabetes drugs, big data, cardiovascular disease, diabetes, diabetic heart disease, drug benefits, drug development, drug side effects, drug targets, genetic variant, genomics, GlaxoSmithKline, GLP1R, heart disease, investigational drugs, liraglutide, Mendelian randomization, PMI, precision medicine, Precision Medicine Initiative cohort, T2D, type 2 diabetes, Victoza