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Progeria International Scientific Workshop

Posted on by Dr. Francis Collins

Dr. Collins playing a guitar with children looking on.

I enjoyed presenting some of my lab’s work at the Progeria Research Foundation’s 9th International Scientific Workshop and later meeting with some of the kids in attendance. Here, I got to sing a song for 17-year-old Meghan (left) from the United States and 2-year-old Alptug (middle) from Turkey. The workshop was held in Cambridge, MA from September 20-22, 2018. Credit: Carol Moroney.


Snapshots of Life: Virus Hunting with Carbon Nanotubes

Posted on by Dr. Francis Collins

H5N2 trapped in carbon nanotubes

Credit: Penn State University

The purple pods that you see in this scanning electron micrograph are the H5N2 avian flu virus, a costly threat to the poultry and egg industry and, in very rare instances, a health risk for humans. However, these particular pods are unlikely to infect anything because they are trapped in a gray mesh of carbon nanotubes. Made by linking carbon atoms into a cylindrical pattern, such nanotubes are about 10,000 times smaller than width of a human hair.

The nanotubes above have been carefully aligned on a special type of silicon chip called a carbon-nanotube size-tunable-enrichment-microdevice (CNT-STEM). As described recently in Science Advances, this ultrasensitive device is designed to capture viruses rapidly based on their size, not their molecular characteristics [1]. This unique feature enables researchers to detect completely unknown viruses, even when they are present in extremely low numbers. In proof-of-principle studies, CNT-STEM made it possible to collect and detect viruses in a sample at concentrations 100 times lower than with other methods, suggesting the device and its new approach will be helpful in the ongoing hunt for new and emerging viruses, including those that infect people.