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Cool Videos: Starring the Wiring Diagram of the Human Brain

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MRI videoThe human brain contains distinct geographic regions that communicate throughout the day to process information, such as remembering a neighbor’s name or deciding which road to take to work. Key to such processing is a vast network of densely bundled nerve fibers called tracts. It’s estimated that there are thousands of these tracts, and, because the human brain is so tightly packed with cells, they often travel winding, contorted paths to form their critical connections. That situation has previously been difficult for researchers to image three-dimensional tracts in the brain of a living person.

That’s now changing with a new approach called tractography, which is shown with the 3D data visualization technique featured in this video. Here, researchers zoom in and visualize some of the neural connections detected with tractography that originate or terminate near the hippocampus, which is a region of the brain essential to learning and memory. If you’re wondering about what the various colors represent, they indicate a tract’s orientation within the brain: side to side is red, front to back is green, and top to bottom is blue.


Creative Minds: Fighting Cancer with Supercomputers

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Amanda Randles

Amanda Randles

After graduating college with degrees in physics and computer science, Amanda Randles landed her dream first job. She joined IBM in 2005 to work on its Blue Gene Project, which had just unveiled the world’s fastest supercomputer. So fast, in fact, it’s said that a scientist with a calculator would have to work nonstop for 177,000 years to perform the operations that Blue Gene could complete in one second. As a member of the applications team, Randles was charged with writing new code to make the next model run even faster.

Randles left IBM in 2009 for graduate school, with the goal to apply her supercomputing expertise to biomedical research. She spent the next several years developing the necessary algorithms to produce a high-resolution 3D model of the human cardiovascular system, complete with realistic blood flow. Now, an assistant professor at Duke University, Durham, NC, and a 2014 NIH Director’s Early Independence awardee, Randles will build on her earlier work to attempt something even more challenging: simulating the movement of cancer cells through the circulation to predict where a tumor is most likely to spread. Randles hopes all of her late nights writing code will one day lead to software that helps doctors stage cancer more precisely and gives patients accurate personalized computer simulations that put an earlier, potentially life-saving bullseye on secondary tumors.