pollen
Possible Explanation for Why Some People Get More Colds
Posted on by Dr. Francis Collins
Getty Images/yourstockbank
Colds are just an occasional nuisance for many folks, but some individuals seem to come down with them much more frequently. Now, NIH-funded researchers have uncovered some new clues as to why.
In their study, the researchers found that the cells that line our airways are quite adept at defending against cold-causing rhinoviruses. But there’s a tradeoff. When these cells are busy defending against tissue damage due to cigarette smoke, pollen, pollutants, and/or other airborne irritants, their ability to fend off such viruses is significantly reduced [1].
The new findings may open the door to better strategies for preventing the common cold, as well as other types of respiratory tract infections caused by non-flu viruses. Even small improvements in prevention could have big implications for our nation’s health and economy. Every year, Americans come down with more than 500 million colds and similar infections, leading to reduced work productivity, medical expenses, and other costs approaching $40 billion [2].
Imaging Advance Offers New View on Allergic Asthma
Posted on by Dr. Francis Collins
Caption: OR-OCT images of the airways of a healthy person (left) and a person with allergic asthma (right). The colorized portion highlights airway smooth muscle, with thinner areas in purple and black and thicker areas in yellow and orange. Credit: Cho et al., Science Translational Medicine (2016)
You probably know people who sneeze a little when they encounter plant pollens, pet dander, or other everyday allergens. For others, however, these same allergens can trigger a serious asthma attack that can make breathing a life-or-death struggle. Now, two NIH-funded research groups have teamed up to help explain the differences in severity underlying the two types of reactions.
In the studies, researchers at Massachusetts General Hospital, Boston, used an innovative imaging tool to zoom in on a person’s airways safely in real time to gain an unprecedented view of how his or her body reacts to allergens [1,2]. The imaging revealed key differences between the asthma and non-asthma groups in the smooth muscle tissue that surrounds critical airways, and is responsible for constriction. In a complementary series of experiments, researchers also uncovered heightened immune responses in the airways of folks with allergic asthma. The findings offer important new clues in the quest to better understand and guide treatment for asthma, a condition that affects more than 300 million people around the world.
The factors driving airway constriction in people with asthma have been poorly understood in part because, until now, there hasn’t been a way to view airway smooth muscle in action. As described in the journal Science Translational Medicine, Melissa Suter and colleagues adapted an established form of imaging called optical coherence tomography (OCT) to help fill this gap. Standard OCT produces an image by measuring the amount of light reflected back from body tissues, but such images aren’t sufficient to distinguish airway smooth muscle from other tissues.
Snapshots of Life: Allergen Art
Posted on by Dr. Francis Collins
Credit: Edna, Gil, and Amit Cukierman, Fox Chase Cancer Center, Philadelphia
Seasonal allergy sufferers, allow me to take advantage of the powers of confocal microscopy to introduce you to your tormenter: pollen. Although pollen grains look amazing at this magnification, their effects on many of us are not so wonderful. These spiky spheres can trigger an immune reaction that produces the runny nose, itchy eyes, and other symptoms that make people with pollen allergies miserable from early spring through late fall.
In fact, this image was created by a seasonal allergy sufferer who also happens to be a cell biologist. On a Saturday afternoon about a decade ago, Edna Cukierman of Philadelphia’s Fox Chase Cancer Center had just received a new spinning disc confocal microscope and couldn’t wait to try it out. There was just one catch—she also had to watch her two children. Not to be deterred, this multi-tasking scientist/mom turned the process of calibrating her new microscope into a creative way of entertaining her kids.
