For obese people with diabetes, doctors have increasingly been offering gastric bypass surgery as a way to lose weight and control blood glucose levels. Short-term results are often impressive, but questions have remained about the long-term benefits of such operations. Now, a large, international study has some answers.
Soon after gastric bypass surgery, about 50 percent of folks not only lost weight but they also showed well-controlled blood glucose, cholesterol, and blood pressure. The good news is that five years later about half of those who originally showed those broad benefits of surgery maintained that healthy profile. The not-so-good news is that the other half, while they generally continued to sustain weight loss and better glucose control, began to show signs of increasing risk for cardiovascular complications.
Tags: bariatric surgery, blood glucose, blood pressure, cardiovascular disease, cholesterol, clinical trial, composite triple endpoint, diabetes, gastric bypass, heart attack, heart disease, hemoglobin A1C, obesity, Roux-en-Y procedure, sleeve gastrectomy, stroke, surgery, type 2 diabetes, weight
Obesity involves the complex interplay of diet, lifestyle, genetics, and even the bacteria living in the gut. But there are other less-appreciated factors that are likely involved, and a new NIH-supported study suggests one that you probably never would have imagined: antenna-like sensory projections on brain cells.
The study in mice, published in the journal Nature Genetics , suggests these neuronal projections, called primary cilia, are a key part of a known “hunger circuit,” which receives signals from other parts of the body to control appetite. The researchers add important evidence in mouse studies showing that changes in the primary cilia can produce a short circuit, impairing the brain’s ability to regulate appetite and leading to overeating and obesity.
Tags: ADCY3, Alström syndrome, appetite, Bardet-Biedl syndrome, brain, cell biology, childhood obesity, ciliopathies, eating, fat, food, Greenland, hunger circuit, hypothalmus, leptin, MC4R neurons, melanocortin 1 receptor gene, neurons, obesity, obesity genes, overweight, Pakistan, polydactyly, primary cilia, weight