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neuron

Watching Neuron Attachments in Real Time

Posted on by Dr. Francis Collins

Bright neon yellow and green blob with many light green fingers dotted with green and red radiating from it.

Caption: A living cortical neuron in a culture dish. Red and green dots reveal synapses—potential communication junctions between neurons.
Credit: Don Arnold, University of Southern California

This glittering web is actually a live nerve cell, or neuron, in which its branches are labeled with glowing probes. Each dot reveals a potential junction between neurons—called a synapse—where chemicals are released allowing the cells to talk to each other. The red dots reveal inhibitory synapses—which silence electrical signals—whereas the green dots show the excitatory synapses that promote electrical signals.


The Symphony Inside Your Brain

Posted on by Dr. Francis Collins

Grid of major pathways in human brain’s left hemisphere. Using diffusion spectrum imaging, which tracks movement of water through nerve fibers, researchers can trace groups of neurons as they cross from one region of the brain to another in living individuals. Credit: Van Wedeen, Massachusetts General/Harvard Medical School

Ever wonder what is it that makes you, you? Depending on whom you ask, there are a lot of different answers, but these days some of the world’s top neuroscientists might say: “You are your connectome.”

The connectome refers to the exquisitely interconnected network of neurons (nerve cells) in your brain. Like the genome, the microbiome, and other exciting “ome” fields, the effort to map the connectome and decipher the electrical signals that zap through it to generate your thoughts, feelings, and behaviors has become possible through development of powerful new tools and technologies.

For some time, neuroscientists have been able to infer loosely the main functions of certain brain regions by studying patients with head injuries, brain tumors, and neurological diseases—or by measuring levels of oxygen or glucose consumption in healthy people’s brains during particular activities. But all along it’s been rather clear that these inferences were overly simplistic.  Now, new advances in computer science, math, and imaging and data visualization are empowering us to study the human brain as an entire organ, and at a level of detail not previously imagined possible in a living person.


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