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histidine kinase

LabTV: Curious About Bacteria

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Robert Morton IIIOther than wondering what might be lurking in those leftovers stashed in the back of the fridge, you probably don’t think much about bacteria. But Robert Morton III—a Ph.D. candidate at Indiana University, Bloomington, and the focus of our latest LabTV profile—sure does. He’s fascinated by the complicated and even beautiful ways in which bacteria interact with their environments. In fact, scientists can learn a whole lot about biology by studying bacteria and other single-celled organisms.

Working in the NIH-funded lab of Yves Brun, Morton has spent many of his days peering through microscopes into the otherwise invisible world of bacteria. His sights are set on the relatively simple, two-component interactions that enable bacteria to sense and respond to various external factors. Each of these interactions features a histidine kinase sensor partnered with a response regulator. Specifically, Morton has focused much of his research on one particular protein thought to play a role in these interactions—a protein that he calls an “orphan” because no scientist has yet identified its partner or determined quite what it does.