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Could Flavanols Reverse Age-Related Memory Decline?

Posted on by Dr. Francis Collins

Cocoa pods, beans, and powder

Caption: Cocoa beans and cocoa powder, which are rich in antioxidant compounds called flavanols.
Credit: Mars Inc.

As we get older, remembering new stuff—an updated computer password or the name of that person whom we met last night (or was it two nights ago?)—can bring a busy day to a head-scratching halt. But are these “senior moments” just something that we have to accept? Maybe not.

In a study published in Nature Neuroscience, a research team partially funded by NIH has provided evidence that changes in a specific brain region are associated with age-related memory loss [1].  And they found that they could reverse this loss by boosting activity in this part of the brain, called the dentate gyrus. What’s especially interesting is that this boost came from a drink that was specially formulated to be rich in flavanols, a group of antioxidant compounds found in cocoa beans. Sounds like every chocolate lover’s dream! But let’s drill down a little deeper.