Lung-on-a-Chip Reveals Disease Secrets
Posted on by Dr. Francis Collins
Tissue engineering is turning into a very powerful tool to learn about biology. We haven’t quite figured out how to grow full sized replacement organs, but we’re able to cultivate miniature versions on a chip. These organs-on-a-chip are poised to revolutionize and fast-track drug discovery and development.
Already a new lung-on-a-chip, developed by NIH-funded investigators at the Wyss Institute in Boston, MA, is a game changer. This nifty little thumb-sized device offers a new way to model human diseases, and a cheaper and faster way to screen potential drugs.
Currently, molecules that are promising drug candidates are tested in test tubes or Petri dishes, then in animals, and then, if they’re successful, in a series of human clinical trials. It’s a long, costly process that, on average, takes about 14 years from discovery to clinic with a price tag of up to $2 billion.