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Deciphering Secrets of Longevity, from Worms

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Microscopic view of a glowing green worm

Caption: Long-lived worms show increased activation of DAF-16 (green), a protein linked with longevity in worms and humans.
Credit: Kapahi Lab, Buck Institute for Research on Aging, Novato, CA

How long would you want to live, if you could remain healthy? New clues from experiments done in microscopic worms suggest that science may have the potential to extend life spans dramatically.

Taking advantage of the power of the worm Caenorhabditis elegans (C. elegans) as a model system for genetic studies, NIH-funded researchers at the Buck Institute for Research on Aging in Novato, CA, decided to set about testing ways to extend the worms’ lifespan.