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Alzheimer’s disease

Posing with Alzheimer’s Research Advocate Max Rosenberg

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Max Rosenberg and Francis Collins

While at the Alzheimer’s Impact Movement (AIM) Advocacy Forum in Washington, DC on June 18, 2018, I posed for a “selfie” with the 15-year-old Alzheimer’s advocate Max Rosenberg. When not in school, Max helps take care of his grandmother who was diagnosed with Alzheimer’s six years ago.
Credit: Max Rosenberg

Teaching Computers to “See” the Invisible in Living Cells

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Brain Cell Analysis

Caption: While analyzing brain cells, a computer program “thinks” about which cellular structure to identify.
Credit: Steven Finkbeiner, University of California, San Francisco and the Gladstone Institutes

For centuries, scientists have trained themselves to look through microscopes and carefully study their structural and molecular features. But those long hours bent over a microscope poring over microscopic images could be less necessary in the years ahead. The job of analyzing cellular features could one day belong to specially trained computers.

In a new study published in the journal Cell, researchers trained computers by feeding them paired sets of fluorescently labeled and unlabeled images of brain tissue millions of times in a row [1]. This allowed the computers to discern patterns in the images, form rules, and apply them to viewing future images. Using this so-called deep learning approach, the researchers demonstrated that the computers not only learned to recognize individual cells, they also developed an almost superhuman ability to identify the cell type and whether a cell was alive or dead. Even more remarkable, the trained computers made all those calls without any need for harsh chemical labels, including fluorescent dyes or stains, which researchers normally require to study cells. In other words, the computers learned to “see” the invisible!