α4β7 antibody therapy
Posted on by Dr. Francis Collins
The surprising results of an animal study are raising hopes for a far simpler treatment regimen for people infected with the AIDS-causing human immunodeficiency virus (HIV). Currently, HIV-infected individuals can live a near normal life span if, every day, they take a complex combination of drugs called antiretroviral therapy (ART). The bad news is if they stop ART, the small amounts of HIV that still lurk in their bodies can bounce back and infect key immune cells, called CD4 T cells, resulting in life-threatening suppression of their immune systems.
Now, a study of rhesus macaques infected with a close relative of HIV, the simian immunodeficiency virus (SIV), suggests there might be a new therapeutic option that works by a mechanism that has researchers both excited and baffled . By teaming ART with a designer antibody used to treat people with severe bowel disease, NIH-funded researchers report that they have been able to keep SIV in check in macaques for at least two years after ART is stopped. More research is needed to figure out exactly how the new strategy works, and whether it would also work for humans infected with HIV. However, the findings suggest there may be a way to achieve lasting remission from HIV without the risks, costs, and inconvenience associated with a daily regimen of drugs.
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Tags: AIDS, antibodies, antiretroviral therapy, art, bnAbs, broadly neutralizing antibodies, CD4 cells, CD4 T cells, Crohn's disease, designer antibody, gastrointestinal tract, HIV, HIV remission, HIV treatment, HIV vaccine, human immunodeficiency virus, immunity, immunology, immunosuppression, integrin, intestine, α4β7, α4β7 antibody therapy, NIH Clinical Center, retrovirus, simian immunodeficiency virus, SIV, T cells, ulcerative colitis, vedolizumab, virology, virus