Graphic showing three mice in a row. The mouse on the left is labeled lean and has an arrow pointing to the middle, fatter mouse which is labeled obese. This arrow indicates the mouse was given a high fat diet and has an anxious look (squinty eye with stress lines). The words “increased senescent cells, increased anxiety” are under this middle mouse. The mouse on the right is also labeled obese but no longer has an anxious look. An arrow pointing from the middle mouse to this one indicates treatment with a senolytic drug. The words “decreased senescent cells, decreased anxiety” are under it.