Skip to main content

Is One Vaccine Dose Enough After COVID-19 Infection?

Posted on by Dr. Francis Collins

COVID-19 vaccination record card
Credit: iStock/Bill Oxford

For the millions of Americans now eligible to receive the Pfizer or Moderna COVID-19 vaccines, it’s recommended that everyone get two shots. The first dose of these mRNA vaccines trains the immune system to recognize and attack the spike protein on the surface of SARS-CoV-2, the virus that causes COVID-19. The second dose, administered a few weeks later, boosts antibody levels to afford even better protection. People who’ve recovered from COVID-19 also should definitely get vaccinated to maximize protection against possible re-infection. But, because they already have some natural immunity, would just one shot do the trick? Or do they still need two?

A small, NIH-supported study, published as a pre-print on medRxiv, offers some early data on this important question [1]. The findings show that immune response to the first vaccine dose in a person who’s already had COVID-19 is equal to, or in some cases better, than the response to the second dose in a person who hasn’t had COVID-19. While much more research is needed—and I am definitely not suggesting a change in the current recommendations right now—the results raise the possibility that one dose might be enough for someone who’s been infected with SARS-CoV-2 and already generated antibodies against the virus.

These findings come from a research team led by Florian Krammer and Viviana Simon, Icahn School of Medicine at Mount Sinai, New York. The researchers reasoned that for folks whose bodies have already produced antibodies following a COVID-19 infection, the first shot might act similarly to the second one in someone who hadn’t had the virus before. In fact, there was some anecdotal evidence suggesting that previously infected people were experiencing stronger evidence of an active immune response (sore arm, fever, chills, fatigue) than never-infected individuals after getting their first shots.

What did the antibodies show? To find out, the researchers enlisted the help of 109 people who’d received their first dose of mRNA vaccines made by either Pfizer or Moderna. They found that those who’d never been infected by SARS-CoV-2 developed antibodies at low levels within 9 to 12 days of receiving their first dose of vaccine.

But in 41 people who tested positive for SARS-CoV-2 antibodies prior to getting the first shot, the immune response looked strikingly different. They generated high levels of antibodies within just a few days of getting the vaccine. Compared across different time intervals, previously infected people had immune responses 10 to 20 times that observed in uninfected people. Following their second vaccine dose, it was roughly the same story. Antibody levels in those with a prior infection were about 10 times greater than the others.

Both vaccines were generally well tolerated. But, because their immune systems were already in high gear, people who were previously infected tended to have more symptoms following their first shot, such as pain and swelling at the injection site. They also were more likely to report other less common symptoms, including fatigue, fever, chills, headache, muscle aches, and joint pain.

Though sometimes it may not seem like it, COVID-19 and the mRNA vaccines are still relatively new. Researchers haven’t yet been able to study how long these vaccines confer immunity to the disease, which has now claimed the lives of more than 500,000 Americans. But these findings do suggest that a single dose of the Pfizer or Moderna vaccines can produce a rapid and strong immune response in people who’ve already recovered from COVID-19.

If other studies support these results, the U.S. Food and Drug Administration (FDA) might decide to consider whether one dose is enough for people who’ve had a prior COVID-19 infection. Such a policy is already under consideration in France and, if implemented, would help to extend vaccine supply and get more people vaccinated sooner. But any serious consideration of this option will require more data. It will also be up to the expert advisors at FDA and Centers for Disease Control and Prevention (CDC) to decide.

For now, the most important thing all of us can all do to get this terrible pandemic under control is to follow the 3 W’s—wear our masks, wash our hands, watch our distance from others—and roll up our sleeves for the vaccine as soon as it’s available to us.

Reference:

[1] Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine. Krammer F et al. medRxiv. 2021 Feb 1.

Links:

COVID-19 Research (NIH)

Krammer Lab (Icahn School of Medicine at Mount Sinai, New York, NY)

Simon Lab (Icahn School of Medicine at Mount Sinai)

NIH Support: National Institute of Allergy and Infectious Diseases

221 Comments

  • Nana says:

    Anyone who had bad reactions after the first dose of vaccine go ahead and have the second? And did you do better, worse the same? I am scared to get the second as I am having such a bad reaction to the first, which I had last Thurs (Pfizer) and I am still sick. I may have had Covid back before we were being warned about it (Feb, 2020 I traveled by plane and got sick 10 days after getting home). I am so miserable don’t think I can handle another shot! And if my immune system is reacting this strongly surely I don’t need another one?

    • Linda L says:

      Debated about it and expressed my concerns here. Because I couldn’t figure out how I would get it if I missed my second appointment decided to get it. For me it wasn’t nearly as bad as with the first.

      • Karen says:

        Linda, do you know your blood type and if so, what is it? Also, was it Moderna or Pfizer? Was wondering if type Os might have less of a reaction the second time around vs type As, who I hypothesized might have worse reaction with second dose. Note: This is entirely my own musing based purely on conjecture and some knowledge of blood type science.

        • Maryann says:

          I am a 74 yr old type A+ and I had 2 doses of Pfizer. I had no reaction to the first dose and barely anything with the 2nd. I kept waiting for soreness, headache, etc. It was so minor that compared to a flu vaccine it was negligable.

          • Karen says:

            Thanks for that response. Had you tested positive or negative for covid-19 at any time prior to the vaccination(s)?

        • Linda L says:

          Karen, I am B+. Had Pfizer. Two weeks after second one I am still very tired.

          • Karen says:

            Linda, thanks for response. After the first Pfizer shot, did you experience any adverse reactions? And with the second, did you experience anything untoward in addition to the fatigue?

          • Linda L says:

            Karen, the first time I had a horrible headache, very bad chills, joint and muscle pain, fever of 101, nausea, my tinnitus got worse, my eyes hurt. I was weak an very tired. This lasted four days. On the fourth day I developed an itchy red patch around the injection site and arm pain. That disappeared a a few days. The fatigue lasted up to second shot. Then it continued. Two weeks later I am still very tired. I had no fever that I am aware of just a mild headache that came and went, snd occasional light chills and occasional sweats at night. I have joint and muscle pain that is still hanging on from the first shot, but have been able to work.

          • maryann says:

            Hi Karen, I’m not certain if your question was directed towards me but if it was, then no, I was never tested for covid 19 at any time.

      • Debbie B says:

        Good to know. Hope this runs to true for husband and I.

    • Carrie says:

      Hi My daughter had such a bad reaction after the first shot she wound up in the ER after 24 hours with her eyes swollen shut, a severe migraine and just no energy. Even after being put on a steroid etc, on day 4 she developed a rash all over her front torso. She also told me she had 2 moments where she almost passed out one the first day about a hour after the shot was given. She had a follow up with her primary doctor today and they said to skip the 2nd shot. It was not worth taking a chance of more severe side effects. Quite honestly her doctor said they do not have enough information about side effects to know if she is a candidate for future boosters.

      • Omar says:

        Wow. Moderna or Pfizer?

      • Jake LaMotta says:

        I truly believe some of the shot givers are failing to dilute the shot. I saw a warning label that said “MUST BE DILUTED”. I had covid back in Aug 2020, fever 12 days, cough for 4, tired, achy. Then weak and felt out of breath for 3 weeks. but was fine after that. I shoveled 6 yards of dirt in December, felt good. I’m 55. Not fat, not diabetic, slight ashma from pollen sometimes.
        14 hours After my first Pfizer vaccine, I had chills, body aches, fever 102, tired. Felt bad for 3 days. Now I feel great though. I go for my second tomorrow, wondering how it will be.

    • Paula says:

      Same with me – I had Covid in June and my first shot was horrible. 48 hours constant pain in my head. Not sure I can get the second one.

    • Diane says:

      Read the recent NYT articles that shows in small studies that those who had COVID and then had one dose of Pfizer or Moderna might not need a second shot. I had COVID a few months ago and got so sick with the first Moderna shot. This article confirms that a second shot may not be necessary in my case and the recommendations may change down the road to just one shot for those who already had COVID. I will not be getting the second vaccine. Any comments?

      • Linda Goodman says:

        Could you possibly provide the dates and titles of the articles? Thanks.

      • Holly H. says:

        I do not get my 2nd vaccine until the 10th of April. I will however write to our blog after I get it. My husband and I both had reactions to the first vaccine. However we had COVID back in January, so we kind of expected a reaction.

      • Lisa Hawk says:

        I too had a bad reaction from my first Moderna shot and also Covid last July. But if I skip my second shot, am I still going to be able to travel to another country with only one shot on my vaccination card?

      • Annie in OH says:

        I am 99% sure I had Covid in March 2020. Headaches, nose running like a faucet, dry cough, extreme fatigue, muscle and joint pain, lost my sense of taste and smell for a couple of days. Felt better after a couple of weeks. No Covid tests given at the time unless you ended up in hospital, which I didn’t. Developed what I believe was long Covid because for the next 5 months, I would feel better one day, try to do too much, and end up feeling lousy again for days after. Finally began feeling fairly good in August but then my right knee got really painful for no apparent reason and could barely walk for days. Used to run several times a week. Can no longer do that since last summer. I had my first Moderna vaccine on March 6, 2021. My second jab is scheduled for April 3rd. My reaction to the first Moderna was sore shoulder, fatigue but difficulty getting to sleep, vivid dreams, headaches for a couple of days, muscle pain off and on for a couple of weeks-especially in my legs. However, I finally feel better-maybe than I did before I had the first jab. Seem to be able to do things I struggled with last summer-like working outside in the yard after already walking a couple of miles with my dog. I’ve been reading anything I can get my hands on about getting the second vaccine if you’ve had Long Covid. My gut is telling me not to get it on the scheduled date but haven’t canceled my appointment yet. I have the feeling they will soon come out with a booster to address the variants and would rather just wait to get a booster down the road. Does anyone know of an accurate test to check your antibody levels for Covid-19 after getting the first vaccine? That would be so helpful to so many of us in deciding whether or not it is wise or necessary to get the second vaccine so soon after our first. My biggest fear is that this second jab on April 3rd will bring back my Long Covid or make me feel worse now that I’m finally feeling better after a year of feeling unwell.

    • Peg says:

      Tested positive for Covid in June. Had flu like symptoms ( fever, headache, body aches and listlessfor a week) but no respiratory issues. Tested positive for antibodies for over 8 mo. Got the first Pfizer dose 3 weeks ago and had headache for 48 hrs and really sore arm for 5 days. Decided not to get second dose and canceled appt. I may decide to get it in a month or 2 but after reading so many with bad reactions and this article I may not get second dose at all. I am 65 and type A.

      • Holly says:

        My 2nd vaccine is not until April 10th. I am going ahead and having it and so is my husband. We are flying to Hawaii in July so feel we best get it. We both had COVID in Jan 2021 for 14 days. We had our first Moderna on March 12th. We both felt sick for about 36 hours. I am just planning to be sick for the 2nd shot. I will write a replay after my 2nd shot!!! We must definitely help each other. Good to see other peoples responses.

    • Chris says:

      I had my 1st Moderna shot yesterday and I’m feeling poorly today – bad headache, chills, tired, sore arm. I had covid in December and the way I’m feeling today reminds me of how I felt when I was sick. I’m leaning against the 2nd shot – especially after reading this article. I just don’t want to be laid up for a week or two with covid-like symptoms. And if the article proves to be correct, than my immunity is likely as high if not higher than many who have had 2 shots. I’ll wait it out to see what the CDC learns in the coming months. Honestly, I just don’t want to suffer anymore.

  • Maryann says:

    Why is it nearly impossible to get a test for antibodies to the ‘spike’ protein which is the focus and target of the Covid vaccines? The antibody test currently available is not applicable to a quantitative measurement of antibodies resulting from either Mrna vaccines. It only measures antibodies produced by the body after having had actual Covid infection ( N protein). It’s just a blood test.

    • Omar says:

      Good question.

    • Tisha B. says:

      I was so terribly sick after my first dose, I threw up all night abs I never throw up. My body ached and I was so sick and nauseous. I got the first shot Sunday March 21. 45 , very active and healthy I did an intense hot yoga that mornkng like I always do, played pickle ball then got the vaccine at 330. I started committing that night at 10. Spent the whole next day in bed. I am a go getter, nothing usually gets me down. I do have an autoimmune disorder pernicious anemia, and I did have cancer in 2019. Im so afraid to get the second dose.

  • Paula says:

    I had Covid last June and just received my first dose and felt worse than when I had Covid. I’m not sure if I can go through with the second shot. Besides all the side effects mentioned, the worst was relentless headache for 48 hours straight. Any suggestions would be appreciated.

    • Diane says:

      Hi, Paula. I am in the same boat and I decided not to have the second vaccine because there may be little added value immune-wise. The decision that one dose may be enough for people who have had COVID and one vaccine makes a lot of sense to me and is supported by these small studies. The thing is that it takes so long for the Government to come out with a recommendation, so I have just decided to skip the second dose and maybe get an antibody test to see how I responded.

      • Paula says:

        I agree and think I’m going to skip my 2nd shot too. I hope it doesn’t impact my ability to travel.

        • Diane says:

          I agree. There may be policies to get into other countries and I don’t want to be restricted. It is a really hard decision but I think I have to go with what makes the most sense to me. Also,if there are unknown long term sequelae we don’t know about, getting one vaccine could possibly minimize that down the road.

          • Chris says:

            It’s nice to know there are others out there who feel the way I do. I had covid in December and had my first shot yesterday – I feel like I did when I had covid so I won’t be getting a second shot. I’m worried about travel restrictions too.

          • Holly says:

            I agree. I will get two vaccines. I had Covid in January for about 14 days. I got my first vaccination two weeks ago and had mild side effects, mostly chills. I will get my 2nd in two weeks. The Moderna. I just plan to not feel well for 48 hours.
            We are planning a trip to Hawaii so figure best get two shots.

  • Marlene Coats says:

    On Dec. 21st I started running a high fever for 11 Days. My fever bounced between 101 and 103 continuously. Dr. called in COVID Test for the 24th of Dec. it came back negative. 2 Days later went to ER fever would not come down very sick and even though I was drinking lots of fluids I was dehydrated. They gave me fluids and also tested me for COVID came back negative. Tested me for both types of flu came back negative so they ended up giving me a strong antibiotic and Sent me home. Three days later my fever is staying on the higher side hoovering around 103. I could not stand it any longer thought I was surley going to die. My husband took me back to Dr. Office. They had to put me in wheelchair I was soooo weak! He tested again for COVID came back negative. He gave me steriods and sent me home. Finally my fever started subsiding and on Jan 1st I had my first fever free day!! Thank GOD! Anyway I had my first dose of the Maderna Vaccine last Friday 12th at 9:00 AM. I worked the rest of the day and around 5:00PM. I started running fever. By 10:00 PM my fever was 102.5 started taking tylenol for fever never went away and by 11:00 AM Saturday morning my fever was 104! I felt horrible. Called ER “did not really want to go in” They said to put ice on wrist, in between elbows, etc. I had to do that on 3 different occasions over the weekend. My fever broke on Sunday around 6:00 PM. After that felt very tired and sluggish, Had horrible headache. Felt bad on Monday but was able to work. Tuesday I was fine. Checking with my Dr. on what I should do regarding my second shot.

  • Lynn DA says:

    I was 3 1/2 months post Covid infection when I had my first Moderna shot on March 17. Felt fine all that day. Morning of the 18th I couldn’t get out of bed. I felt like a truck hit me. Symptoms were similar to the actual disease, but more intense. Fever, chill, headache, body aches, dizziness and fatigue. The following day was only slightly better. Today is day 3 post-vaccine and was still not back to normal until mid-day.
    I’m hoping someone addresses this issue for those of us that had such a bad reaction, at this time I can’t conceive of going back for the second shot. At least not in 28 days.

  • Sara says:

    I had COVID in November. I had the first Moderna vaccine on 3/19. It has been awful. I feel like I’ve been hit by a truck. My skin hurts, my eyes burn, my head is throbbing, I have zero energy (as in, I have to convince myself to get up and use the bathroom), I’m so tired, my fever got up to 102.7, my lymph nodes are huge, constant chills, can’t get comfortable. It’s awful. I am terrified of getting the second dose. The vaccine was worse than having COVID.

  • Cathleen L. says:

    There really needs to be a decision to not get dose #2 of covid-19 vaccine for those who have had recent infection – I had high temp, chills, headache and body aches for 2 days after vaccination. I had been “recovered” from covid-19 for 2 weeks. As a nurse I was advised to receive the vaccine. I am really concerned about going for round 2.

  • Ken says:

    It seems to me that we know several things:
    – Covid-19 testing, both antibody and PCR, have produced less-than totally reliable results as many individuals who have been tested multiple times have received contradictory results.
    – As a result it is often difficult to determine if you definitively have had Covid-19, due to its multitude of symptoms and asymptomatic infections.

    I think it would be foolish to conclude that your first vaccine dose is unnecessary; it will boost your immunity even if you have had Covid-19. Besides, the low probability of reacting to it and feeling sick for a week or two is dwarfed by the high probability (>2% over 75) that you might DIE if you were wrong. That’s not a good bet.

    But then, what if you had Covid-19 symptoms, but either were not tested or received a negative antibody test months later when the test may not have been determinative? And following your first vaccination, you had a severe reaction. What do you do about your second shot?

    This seems to be a cost/benefit question. You can’t really know what the costs of your second shot would be – another week in bed? But what are the benefits? The initial (sparse) data that I have seen on both Pfizer and Moderna have shown no significant statistical difference between the one-shot and two-shot efficacy. There are so few data points that the calculations were a bit fuzzy. These analyses were marred by giving all the patients the second shot, thus discontinuing the one-shot trails after only 3 or 4 weeks.

    This gap in our information is inexcusable. Hopefully some more complete analyses of one-shot efficacy are now underway.

    • Annie in OH says:

      Ken, thank you so much for saying exactly what I’ve been thinking ever since I had my first Moderna vaccine on 3/6/2021. I have no absolute proof that I had Covid-19 in March 2020 but the symptoms were there as well as the many months of Long Covid symptoms that I experienced for much of the rest of the year. The first Moderna vaccine was not as bad for me as some here have described. If I had a really violent first reaction, there would have been no question for me about getting a second jab 3 or 4 weeks later (depending on if you get Pfizer or Moderna). I had a couple days of headaches, 2 weeks of fatigue, restless legs, fascial pain-mostly in my legs, weird tastes and smells. I’ve read everything I could find over the past month about just getting one dose of the vaccine and not following it up so quickly with a second. That’s what they’re doing in many countries in Europe and it seems to be effective plus more people get at least some immunity. I’m not saying I’ll never get a booster, just don’t want to get it so soon. Reading what you and others have written here helps me to feel like the right thing for me is to cancel my appointment for the second dose of Moderna on April 3rd and wait to see where we are with this a few months down the road. Would rather see someone who really wants and needs that first Covid-19 vaccine have my time slot and get some immunity. I’ll continue to double mask up, avoid the gym and indoor dining as I’ve done for the past 12 months.

  • Peg says:

    I honestly wish there were studies and information on the need for the second vaccine for those who have had covid with strong antibodies. My husband and myself had Covid in mid June 2020 and tested positive for antibodies for 9 months so far. Far longer than the CDC says you will have them. I am 65 and became eligible for the vax so I reluctantly got first dose of Pfizer in early March 2021. Hubs still has antibodies (he gives convalescent blood donation. I don’t know if I still had antibodies when I got the vaccine as I wasn’t tested). I had a very sore arm for 5 days (I normally have sore arm 1 day for flu shot) and headaches for 2 days following the first dose. I am scheduled for my second dose this week but I am trying to reschedule to push it out for at least a month. So far have no been able to contact anyone to reschedule. Truthfully afraid to get the second dose and didn’t feel I needed the first dose with the antibodies we have had but felt pushed by younger family members who are fearful. Not sure what to do but running out of time.

  • Eileen F says:

    I tested positive for Covid 12/15/20. Still don’t have sense of taste/smell back 100%, took about 6-8 weeks to feel good. Got my first shot (Pfiser) on 3/15/21. No immediate reaction, but by 9 p.m. I was having shaking chills so bad I couldn’t control my body. I could tolerate the headache which was quite bad, and had trouble seeing, very bad joint pain and fatigue. I started to feel ok 2 days later. I am very concerned about getting a second shot and probably will not get it.

    • Janet Mc. says:

      I fell ill 3 days after the Moderna dose 1; awoke in night with sudden onset of profuse sweating, weak to the point of being unable to get off floor, nausea, vomiting, severe diahhrea, low BP ; family called 911; Hospital kept me in observation overnight on IV fluids and tested for Covid and everything imaginable. All results negative. Told it might have been a reaction to the vaccine.
      I have since met an Allergist and GI MD who note it is suspicious of a reaction as I have no other known health issues that
      would account for the episode. I am greatly concerned and stressed as to whether or not to take Dose 2 this week. Has anyone considered or received the J&J vaccine as the 2nd Dose?

  • Karen says:

    My mother is 92, O-negative. She had the Moderna vaccine: first shot, February 21st at Walgreen’s. We stayed there 45 minutes because she experienced some dizziness at the half-hour mark; in another fifteen minutes, the dizziness had passed, and we left. At about 3:00 that afternoon, she began to get a headache and chills, but nothing severe. Later that night, she had joint pains everywhere she had her usual pains….ie, back, hips, ankles. She has had multiple injuries, and 3 failed back surgeries. She described the pain after vaccination as being “about five times worse” than what she felt normally. The only new pain was a curious one….she said her teeth hurt….but she says in retrospect it wasn’t “that bad”…they just “all seemed to ache a little.” There was only a slight soreness on her arm at the injection site itself. The headache, teeth pain, and increased joint pains lasted about a day and a half, and did not rise to the level of “troublesome.” She had no nausea or vomiting, no breathing problems. Her blood pressure did rise somewhat: the lower number (diastolic) went a bit over 100, and it took about 5 days for that to lower back to her normal. She had extra fatigue, but its duration is hard to gauge because she has fatigue and chronic (musculoskeletal) pain daily. She also has a history of rheumatoid arthritis.

    My mother’s second Moderna shot was on March 21st, again at Walgreen’s. There was no dizziness. It is now 2 days later: she has experienced no joint pain, no teeth pain, no extra fatigue, no headache, no breathing problems, and no nausea. This time around she did have more soreness at the injection site than she did with the first dose, but that has already receded as well. Her blood pressure was a little curious: the diastolic measured at about 55 three times the afternoon and evening after the second injection (systolic at about 160)….by the next day, though, it was down to 138/78. Her norm is about 150/90 (as I write this, however, her BP is 162/113…she does take blood pressure meds….amlodipine and quinapril….but she also had a history of paroxysmal readings prior to first vaccination). Also, she had developed a UTI 2 days before the second injection, for which she has been taking amoxicillin.

    I attribute the relative lack of reaction to the second dose to the possibility that her immune system recognized the spike protein quickly (because of effects of the previous injection) and therefore was able to repel it at entry. I will report back with any new developments; I hope this helps somewhat.

    • Jake LaMotta says:

      oh my, her teeth! I thought I was imagining that! my right upper side teeth felt like someone punched me for a week a couple days after my first Pfizer vaccine.

  • Alan Zahn says:

    I was hospitalized with covid in March 2020. I’m A+ and almost a year to the day got my first Moderna vaccine. Twelve hours after the shot I came down with 102* fever and the worst headache I ever had. I was in pain, uncomfortable and feeling very sick for almost 48 hours. On the fourth day I basically felt fine, but I certainly don’t want to experience that again. I’ve read so many articles about immunologists not believing the second shot is necessary if you already have antibodies (I tested positive for antibodies a couple of weeks prior my vaccination), but it seems like there hasn’t been enough research and the medical/science community is still recommending the second dose for everyone… I hope they figure it out before April 12th (date for my second shot)!

  • Michael N says:

    I had Covid in November and had my first Pfizer shot on March 24th. My arm started hurting about 2 hours after the shot, then I felt ill about 4 hours after the shot. I took some Tylenol and had to lay down for a while. I became fatigued on the 2nd day and had really bad pain in the injection site, slept most of the day. Day 3 I’m still hurting in the arm and feel like I’m under the weather and have no energy. I had 3 other friends get the shot the same day that have never had Covid and they are having no side effects at all. I’m now considering not getting the 2nd dose, I can’t go through this again especially if it is worse. This is almost as bad as having Covid. .

  • David W says:

    The NIH needs to make a statement on this soon. This is not good, if you have had Covid you may not want to get a Vaccine period.

  • Jim says:

    I’m 37, just had my first dose of Moderna a few days ago. Feel fine. Had mild soreness at the injection site and a faint hint of that “I’m getting sick”-type ache in my joints the day of the injection. It’s all cleared up now, though.

  • Hal Stevens says:

    Back around Thanskgiving, Nov. 2019, before anyone knew of the Coronavirus, I had a very strange cold and I wasn’t sick for about a decade before that. I had a sore throat for about a week. It turned into a sinus issue with a cold and maybe a small cough. I also had chills for a few nights and probably a small fever. I wasn’t nauseous and didn’t lose my appetite. In 2 weeks I felt better, but for the next week and a half or so, I got dizzy every time I got up from bed. That had never happened to me before after a bad cold. I’ve been taking the flu vaccine for about 30 years and I know this wasn’t the flu. I’ve read recent stories that Covid-19 might have been here as early as Oct. 2019, and I’ve long suspected whether I had Covid in Nov. 2019.

    Around the same time, a friend who gives me rides to go shopping had a cough he couldn’t get rid of for a few weeks.
    Last week I had my first dose of the Pfizer vaccine. A few hours later, I suddenly felt very cold and tired. I went to bed for about 7 to 8 hours. When I woke up, I felt a good deal better except that I noticed when I sat down, my knee joints made me grunt from slight pain. The same goes for my lower back. I found this article and spoke to a physician friend. He said that if I have no reaction from the 2nd shot, there’s a good chance I had already had the coronovirus.

    I’m just sorry I never took an IgG serology test to see if I had the antibodies. I can’t understand why major cities like NYC didn’t test the areas with the highest positive rates for antibodies to get an idea of the amount of herd immunity there was in those neighborhoods.

  • Monica says:

    Has anyone had Covid and received their first dose with side effects and then gotten a second dose? If so, did you have side effects after the second vaccine? I had many side effects after my first dose. I am worried about getting a second one.

    • Tania M. says:

      I had COVID in December just got the 1st shot a week ago it made me so sick fever, chills, body aches for like two days. I’m supposed to go back on April 12 but I’m truly scared and don’t know what to do if I should go back or not.

      • Holly says:

        I am scheduled for my 2nd COVID vaccine. I had Covid in January. I had the chills etc after the first vaccine. My grand-daughters pediatrician told us that we should NOT have bad side effects after the 2nd vaccine. Hope she is correct.

        • Susan says:

          Holly could you please let me know how your second vaccine goes? I’m nervous about getting the second one after I had side effects from my first.
          Thanks

        • Ann says:

          Holly, thank you for your encouraging post. I spoke with the nurse at my Doctor’s office today and she said the same thing. Now that travel could be hindered if you don’t have a ‘vaccine passport’, I just may keep my second dose appointment. Yikes!

  • Sharon says:

    I had my first dose of Pfizer vaccine. I had some kind of weird feeling movement on my back. I didn’t know what it is. Is it working inside my body from Pfizer vaccine?

  • Susan says:

    Has anyone had covid and gotten both vaccine doses????? What was your experience with the first and then the second? Trying to decide if I should get the second dose.

  • Theresa W. says:

    Anyone have “delayed reactions” to their 1st shot? Got my first Pfizer vaccine two weeks ago. No side effects. 4 days ago started with dry cough, aches, chills, low grade fever and worse of all, excruciating ear pain. Still fighting fatigue & cough. Seems unlikely to be reaction from shot and figure I must have caught covid in between shots. Now waiting for test results. Also, my 2nd dose is scheduled for 3 days from now. How long should I wait to get it after recovering?

  • 1 2 3 4 5

Leave a Reply to MRKRUSSCancel reply

Discover more from NIH Director's Blog

Subscribe now to keep reading and get access to the full archive.

Continue reading