Nanoparticles Create Spirals in the Lungs
Posted on by Dr. Francis Collins
These eye-catching spirals may resemble a trendy print from Diane von Furstenberg’s Spring Collection, but they’re actually a close-up of lung surfactant—a lipid-protein film that coats the inside of the air sacs in the lungs, making it easier to breathe. Made using fluorescence microscopy techniques, this image shows what happens to the surfactant (black) when it interacts with carbon nanoparticles.
Scientists found that carbon nanoparticles rearrange the surfactant molecules from kidney bean shaped clusters into solid spirals. Since carbon nanoparticles may be effective drug delivery vehicles, it’s important to know how these molecules alter the surfactant—and whether these changes are harmful.
The verdict is still out on whether disrupting the surfactant triggers breathing problems, but we can still be mesmerized by the image.
Lipid-protein interactions alter line tensions and domain size distributions in lung surfactant monolayers. Dhar P, Eck E, Israelachvili JN, Lee DW, Min Y, Ramachandran A, Waring AJ, Zasadzinski JA. Biophys J. 2012 Jan 4;102(1):56-65.
As highlighted in Biomedical Beat, a monthly digest of research news from the National Institute of General Medical Sciences, NIH.
NIH support: the National Heart, Lung, and Blood Institute; the National Institute of Environmental Health Sciences; and the National Institute of General Medical Sciences