‘No Ouch’ Vaccine Patch

An enlarged photo of the patch held by tweezers above a second photo of a magnified view of the needles.

A vaccine patch and a view of the “needles” using scanning electron microscopy.
Credit: Peter DeMuth/Wellcome Trust

This might be a new way to get a shot. Funded in part by the NIH, this vaccine patch [1] is coated in a thin film that literally melts into the skin when the patch is applied. The film contains DNA, rather than protein, which is absorbed by the skin cells and triggers an immune reaction. It seems to be effective in animal models. DNA vaccines are attractive because they may not require refrigeration like typical protein vaccines and can be stably stored for weeks. And, though this patch looks spiky, the length of the needles can be adjusted so that they don’t reach the skin layers that contain nerves. Thus: no ouch.

[1] Polymer multilayer tattooing for enhanced DNA vaccination. Demuth PC, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, Irvine DJ. Nat Mater. 2013 Jan 27.

 NIH support: the National Institute of Allergy and Infectious Diseases

7 thoughts on “‘No Ouch’ Vaccine Patch

  1. No pain? That’s seems to be good, but, according to my friend Antonio above, is there any potential risk?

    • Thanks for your questions, Antonio and Endrigo! The main risk of DNA vaccines is that they might not elicit a strong enough immune response to protect someone from disease. But that’s something that researchers are now working to improve. As far as safety, injecting DNA is thought to be less risky to patients than current approaches that involve injecting larger pieces of viruses or bacteria.

  2. This blog is nice and amazing. I really like your post! It’s also nice to see someone who does a lot of research and has a great knack for writing, which is pretty rare from bloggers these days.Thanks!

  3. Isn’t it possible that these vaccines induce tolerance rather than immunity to the encoded antigen?

  4. Thanks for this awesome post about vaccine patch…It is always nice to have such a nice blogger with us..Keep posting like this… It really inspires a lot.

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