What Is Obesity? Metabolic Signatures Offer New Comprehensive View

Silhouettes over an NMR

Credit: Adapted from Elliott, P et al., Sci Transl Med. 2015 Apr 29;7(285)

As obesity has risen in the United States and all around the world, so too have many other obesity-related health conditions: diabetes, heart disease, stroke, cancer, and maybe even Alzheimer’s disease. But how exactly do those extra pounds lead to such widespread trouble, and how might we go about developing better ways to prevent or alleviate this very serious health threat?

In a new study in Science Translational Medicine [1], researchers performed sophisticated analyses of the molecules excreted in human urine to produce one of the most comprehensive pictures yet of the metabolic signature that appears to correlate with obesity. This work provides a fascinating preview of things to come as researchers from metabolomics, microbiomics, and a wide variety of other fields strive to develop more precise approaches to managing and preventing disease.

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Put This Liver To The Test

A photo of a petri dish holding a piece of tissue.

Artificial Liver
Source: NIBIB, NIH

Growth of blood vessels (red) enables implanted human ectopic artificial livers (HEALs) to grow and function in the mouse. This miniature human liver was removed from a HEAL-humanized mouse. Mice implanted with these organs are particularly useful for monitoring drug metabolism, drug-drug interactions, and predicting how certain drugs can damage and destroy the human liver.