Snapshots of Life: Behold the Beauty of the Eye

Colorized cross section of a mouse eye

Credit: Bryan William Jones and Robert E. Marc, University of Utah

The eye is a complex marvel of nature. In fact, there are some 70 to 80 kinds of cells in the mammalian retina. This image beautifully illuminates the eye’s complexity, on a cellular level—showing how these cells are arranged and wired together to facilitate sight.

“Reading” the image from left to right, we first find the muscle cells, in peach, that move the eye in its socket. The green layer, next, is the sclera—the white part of the eye. The spongy-looking layers that follow provide blood to the retina. The thin layer of yellow is the retinal pigment epithelium. The photoreceptors, in shades of pink, detect photons and transmit the information to the next layer down: the bipolar and horizontal cells (purple). From the bipolar cells, information flows to the amacrine and ganglion cells (blue, green, and turquoise) and then out of the retina via the optic nerve (the white plume that seems to billow out across the upper-right side of the eye), which transmits data to the brain for processing.

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Cool Videos: Heart Attack

Blood Clots Video screenshot

Up next in our scientific film fest is an original music video, straight from the Big Apple. Created by researchers at The Rockefeller University, this song-and-dance routine provides an entertaining—and informative—look at how blood clots form, their role in causing heart attacks, and what approaches are being tried to break up these clots.

Before (or after!) you hit “play,” it might help to take a few moments to review the scientists’ description of their efforts: the key to saving the lives of heart attack victims lies in the molecules that control how blood vessels become clogged. This molecular biomedicine music video explains how ischemic injury can be prevented shortly after heart attack symptoms begin: clot blocking. The science is the collaborative work of Dr. Barry Coller of Rockefeller, Dr. Craig Thomas and his colleagues at the National Center for Advancing Translational Sciences (NCATS), and Dr. Marta Filizola and her Mount Sinai colleagues.

Links:

Laboratory of Blood and Vascular Biology, The Rockefeller University

Filizola Laboratory, Icahn School of Medicine at Mount Sinai

Center for Clinical and Translational Science, The Rockefeller University

Clinical and Translational Science Awards (NCATS/NIH)

NIH Common Fund Video Competition

NIH support: Common Fund; National Center for Advancing Translational Sciences

Cool Videos: Accelerating Discoveries Toward Better Health

Clinical and Translational Science video screenshot

One of the biggest challenges in biomedical research today is breaking down the barriers that slow the translation of new scientific discoveries into treatments and cures. Today’s video drives home that point through a parody of the Emmy Award-winning TV series, “Breaking Bad.”

Shot in Albuquerque by the University of New Mexico’s Clinical and Translational Science Center, this film focuses on a dramatic but obviously fictional example of what it takes to move fundamental knowledge about biology into a therapy that can make a difference in a patient’s life. Here’s the plot in a nutshell: “Walter White explains to his class that clinical and translational science is about accelerating basic science to clinical science and then into practice, bringing new discoveries and technology to the people. This parody shows how Walter and Jesse Pinkman bring basic science to clinical practice, and enable a multiple sclerosis (MS) patient to walk again.”

Links:

Clinical & Translational Science Center, University of New Mexico Health Sciences Center

Clinical and Translational Science Awards (National Center for Advancing Translational Sciences/NIH)

NIH Common Fund Video Competition

NIH support: Common Fund; National Center for Advancing Translational Sciences

Cool Videos: Diving for Drugs

Therapies From the Sea video sceenshot

Who says biomedical scientists always have to work indoors? The next installment in our mini-film fest proves otherwise, offering a close-up look at some medicinal chemists who are busy carrying out their research in warm waters off the Florida Keys.

This aquatic adventure may not be as action-packed as “Pirates of the Caribbean” or “Finding Nemo.” But these researchers from the University of Florida College of Pharmacy in Gainesville are out to discover something far more valuable to patients than sunken treasure: marine life with chemical compounds that may provide the basis for new treatments and cures.

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Cool Videos: Myotonic Dystrophy

Myotonic Dystrophy Video screenshot

Today, I’d like to share a video that tells the inspirational story of two young Massachusetts Institute of Technology (MIT) researchers who are taking aim at a genetic disease that has touched both of their lives. Called myotonic dystrophy (DM), the disease is the most common form of muscular dystrophy in adults and causes a wide variety of health problems—including muscle wasting and weakness, irregular heartbeats, and profound fatigue.

If you’d like a few more details before or after watching these scientists’ video, here’s their description of their work:  “Eric Wang started his lab at MIT in 2013 through receiving an NIH Early Independence Award. Learn about the path that led him to study myotonic dystrophy, a disease that affects his family. Eric’s team of researchers includes Ona McConnell, an avid field hockey goalie who is affected by myotonic dystrophy herself. Determined to make a difference, Eric and Ona hope to inspire others in their efforts to better understand and treat this disease.”

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