It may surprise you to learn that the poised young woman featured in this video was a sophomore in high school at the time the film was made. Today, Emily Ashkin is a high school senior with impressive laboratory experience and science awards to her name. As it happens, she’s also introducing me when I deliver a keynote address at the Melanoma Research Alliance’s annual scientific meeting — today, here in Washington, D.C.
What struck me most when I heard Emily’s story was her fearlessness. When mentoring young students, helping some to believe in themselves can be a real challenge. Not Emily. She faces her challenges by seeking solutions, asking—as she does in the video—“Why can’t that be me?”
When Amy Gladfelter arrived at the University of Basel in Switzerland to pursue post-doctoral work in 2001, she remembers that her research interests were still a little up in the air. As she settled into the new lab, Gladfelter remembers watching movies that others had made of the filamentous fungus Ashbya gossypii and wondering how on earth its myriad nuclei could share the same cytoplasm and do different things. Now, more than a decade later, this cell biologist finds herself at Dartmouth College, Hanover, N.H., where she is leading a lab that is making its own thought-provoking movies and pushing the envelope in an effort to answer this and many other scientific questions.
As you’ll learn by watching this video, Gladfelter’s work has implications far beyond the world of fungi because the filamentous proteins called septins, which act to define territory within Ashbya cells, are very similar to certain proteins found in human cells. While such proteins are normally very flexible, they can morph into toxic, solid states in certain human disorders, including Alzheimer’s disease and Huntington’s disease. Besides illustrating the value of Ashbya for uncovering clues to neurodegenerative disorders, this video delivers a broader message about the importance of all kinds of model organisms for efforts to understand our own biology.
If you have ever wondered what it is like to be an oxygen molecule inhaled through the lungs, here is your chance to find out! In this movie, we take a fantastic voyage through the slippery airways of the adult mouse lung.
We begin at the top in the main pipeline, called the bronchus, just below the trachea and wind through a system of increasingly narrow tubes. As you zoom through the airways, take note of the cilia (seen as goldish streaks); these tiny, hair-like structures move dust, germs, and mucus from smaller air passages to larger ones. Our quick trip concludes with a look into the alveoli — the air sacs where oxygen is delivered to red blood cells and carbon dioxide is removed and exhaled.
Wow! It’s one thing to know that the immune system has the power to destroy cancerous cells. But it’s quite another thing to see a cytotoxic T cell actually take out a cancer cell right before your eyes.
This amazing video was produced by Alex T. Ritter as part of Celldance 2014, an annual video series by the American Society for Cell Biology (ASCB). To make this series happen in 2014, ASCB staff contacted cell biology labs known for their sophisticated imaging tools and techniques, asking them to submit proposals for videos. In return, ASCB provided some funding, post-production support from a professional videographer, and an original soundtrack from the up-and-coming Hollywood composer Ted Masur.
There aren’t too many molecular biologists who have spent a 3-month stint in Hollywood. But Janet Iwasa is not your average molecular biologist. After earning her PhD in 2006, she took a break from the lab to take a crash course in animation techniques at the Gnomon School of Visual Effects.
While her classmates produced lots of cool footage worthy of the silver screen, Iwasa wanted to learn how to depict in colorful 3D action, some of the complex molecular processes that are so difficult to convey using static 2D illustration. Among her creations is this 2-minute, rough-draft animation showing how the human immunodeficiency virus (HIV) recognizes and infects a type of immune cell known as a T cell.